Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
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Published:2019-11-12
Issue:1
Volume:10
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Noordam Raymond, Bos Maxime M., Wang HemingORCID, Winkler Thomas W., Bentley Amy R.ORCID, Kilpeläinen Tuomas O., de Vries Paul S., Sung Yun Ju, Schwander KarenORCID, Cade Brian E., Manning AlisaORCID, Aschard HuguesORCID, Brown Michael R., Chen Han, Franceschini Nora, Musani Solomon K., Richard MelissaORCID, Vojinovic Dina, Aslibekyan Stella, Bartz Traci M., de las Fuentes LisaORCID, Feitosa MaryORCID, Horimoto Andrea R., Ilkov Marjan, Kho Minjung, Kraja Aldi, Li Changwei, Lim Elise, Liu Yongmei, Mook-Kanamori Dennis O., Rankinen Tuomo, Tajuddin Salman M., van der Spek AshleyORCID, Wang ZheORCID, Marten JonathanORCID, Laville VincentORCID, Alver Maris, Evangelou EvangelosORCID, Graff Maria E., He MeianORCID, Kühnel Brigitte, Lyytikäinen Leo-PekkaORCID, Marques-Vidal PedroORCID, Nolte Ilja M.ORCID, Palmer Nicholette D.ORCID, Rauramaa Rainer, Shu Xiao-Ou, Snieder HaroldORCID, Weiss StefanORCID, Wen Wanqing, Yanek Lisa R.ORCID, Adolfo CorreaORCID, Ballantyne Christie, Bielak Larry, Biermasz Nienke R., Boerwinkle Eric, Dimou NikiORCID, Eiriksdottir Gudny, Gao Chuan, Gharib Sina A., Gottlieb Daniel J., Haba-Rubio José, Harris Tamara B., Heikkinen SamiORCID, Heinzer Raphaël, Hixson James E., Homuth Georg, Ikram M. ArfanORCID, Komulainen Pirjo, Krieger Jose E.ORCID, Lee JiwonORCID, Liu JingminORCID, Lohman Kurt K., Luik Annemarie I., Mägi Reedik, Martin Lisa W.ORCID, Meitinger Thomas, Metspalu AndresORCID, Milaneschi Yuri, Nalls Mike A., O’Connell Jeff, Peters Annette, Peyser Patricia, Raitakari Olli T., Reiner Alex P., Rensen Patrick C. N.ORCID, Rice Treva K., Rich Stephen S.ORCID, Roenneberg Till, Rotter Jerome I.ORCID, Schreiner Pamela J., Shikany James, Sidney Stephen S., Sims Mario, Sitlani Colleen M., Sofer TamarORCID, Strauch Konstantin, Swertz Morris A., Taylor Kent D.ORCID, Uitterlinden André G.ORCID, van Duijn Cornelia M., Völzke Henry, Waldenberger Melanie, Wallance Robert B., van Dijk Ko WillemsORCID, Yu Caizheng, Zonderman Alan B., Becker Diane M., Elliott PaulORCID, Esko TõnuORCID, Gieger Christian, Grabe Hans J.ORCID, Lakka Timo A., Lehtimäki Terho, North Kari E., Penninx Brenda W. J. H., Vollenweider Peter, Wagenknecht Lynne E., Wu Tangchun, Xiang Yong-Bing, Zheng WeiORCID, Arnett Donna K., Bouchard ClaudeORCID, Evans Michele K., Gudnason VilmundurORCID, Kardia Sharon, Kelly Tanika N., Kritchevsky Stephen B., Loos Ruth J. F.ORCID, Pereira Alexandre C., Province Mike, Psaty Bruce M., Rotimi Charles, Zhu Xiaofeng, Amin Najaf, Cupples L. AdrienneORCID, Fornage Myriam, Fox Ervin F., Guo Xiuqing, Gauderman W. James, Rice Kenneth, Kooperberg Charles, Munroe Patricia B.ORCID, Liu Ching-TiORCID, Morrison Alanna C., Rao Dabeeru C., van Heemst Diana, Redline Susan
Abstract
Abstract
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
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