Mendelian randomization of blood lipids for coronary heart disease

Author:

Holmes Michael V.12,Asselbergs Folkert W.345,Palmer Tom M.6,Drenos Fotios78,Lanktree Matthew B.9,Nelson Christopher P.1011,Dale Caroline E.12,Padmanabhan Sandosh13,Finan Chris1,Swerdlow Daniel I.1,Tragante Vinicius314,van Iperen Erik P.A.415,Sivapalaratnam Suthesh16,Shah Sonia17,Elbers Clara C.1418,Shah Tina1,Engmann Jorgen1,Giambartolomei Claudia17,White Jon17,Zabaneh Delilah17,Sofat Reecha1,McLachlan Stela19,Doevendans Pieter A.3,Balmforth Anthony J.20,Hall Alistair S.20,North Kari E.21,Almoguera Berta18,Hoogeveen Ron C.22,Cushman Mary2324,Fornage Myriam25,Patel Sanjay R.26,Redline Susan26,Siscovick David S.2728,Tsai Michael Y.29,Karczewski Konrad J.30,Hofker Marten H.31,Verschuren W. Monique32,Bots Michiel L.33,van der Schouw Yvonne T.33,Melander Olle34,Dominiczak Anna F.13,Morris Richard35,Ben-Shlomo Yoav36,Price Jackie19,Kumari Meena1,Baumert Jens37,Peters Annette37,Thorand Barbara37,Koenig Wolfgang38,Gaunt Tom R.8,Humphries Steve E.7,Clarke Robert39,Watkins Hugh40,Farrall Martin40,Wilson James G.41,Rich Stephen S.42,de Bakker Paul I.W.1433,Lange Leslie A.43,Davey Smith George8,Reiner Alex P.44,Talmud Philippa J.7,Kivimäki Mika45,Lawlor Debbie A.8,Dudbridge Frank12,Samani Nilesh J.1011,Keating Brendan J.21846,Hingorani Aroon D.1,Casas Juan P.112,

Affiliation:

1. Genetic Epidemiology Group, Institute of Cardiovacular Science, Faculty of Population Healh Sciences, University College London, 1–19 Torrington Place, London WC1E 6BT, UK

2. Division of Transplant Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA

3. Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands

4. Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands

5. Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK

6. Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK

7. Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, Rayne Building, London WC1E 6JF, UK

8. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK

9. Department of Medicine, McMaster University, Hamilton, ON, CanadaL8S 4L8

10. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK

11. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK

12. Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK

13. Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK

14. Department of Medical Genetics, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

15. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands

16. Department of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands

17. Department of Genetics Environment and Evolution, UCL Genetics Institute, 2nd Floor, Darwin Building, Gower Street, London WC1E 6BT, UK

18. Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA

19. Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK

20. Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK

21. Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA

22. Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis and Vascular Medicine, Houston, TX 77030, USA

23. Department of Medicine, University of Vermont, 208 South Park Dr, Colchester, VT 05446, USA

24. Department of Pathology, University of Vermont, 208 South Park Dr, Colchester, VT 05446, USA

25. The University of Texas Health Science Center at Houston, Houston, TX, USA

26. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA

27. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA

28. Department of Epidemiology, University of Washington, Seattle, WA, USA

29. Department of Laboratory Medicine and Pathology, University of Minnesota

30. Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA

31. Department Pathology and Medical Biology, Medical Biology Division, Molecular Genetics, University Medical Center Groningen and Groningen University, Groningen, The Netherlands

32. Centre for Prevention and Health Services Research at National Institute for Public Health and the Environment, Utrecht, The Netherlands

33. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

34. Lund University, Malmö, Sweden

35. Department of Primary Care and Population Health, UCL, Royal Free Campus, Rowland Hill St, London, UK

36. School of Social and Community Medicine, University of Bristol

37. Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

38. Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany

39. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK

40. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

41. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA

42. Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA

43. Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill,NC27514, USA

44. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

45. Department of Epidemiology and Public Health, University College London, 1–19 Torrington Place, London WC1E 6BT, UK

46. Department of Paediatrics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

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