Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-04982-3.pdf
Reference52 articles.
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2. Perez, H. L. et al. Antibody-drug conjugates: current status and future directions. Drug Discov. Today 19, 869–881 (2014).
3. Tsuchikama, K. & An, Z. Antibody-drug conjugates: recent advances in conjugation and linker chemistries. Protein Cell 9, 33–46 (2018).
4. McCombs, J. R. & Owen, S. C. Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry. AAPS J. 17, 339–351 (2015).
5. Younes, A. et al. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N. Engl. J. Med. 363, 1812–1821 (2010).
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