Antibody-drug conjugates: recent advances in conjugation and linker chemistries
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Drug Discovery,Biochemistry,Biotechnology
Link
http://link.springer.com/article/10.1007/s13238-016-0323-0/fulltext.html
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3. Beerli RR, Hell T, Merkel AS, Grawunder U (2015) Sortase enzyme-mediated generation of site-specifically conjugated antibody drug conjugates with high in vitro and in vivo potency. PLoS ONE 10:e0131177
4. Behrens CR, Ha EH, Chinn LL, Bowers S, Probst G, Fitch-Bruhns M, Monteon J, Valdiosera A, Bermudez A, Liao-Chan S et al (2015) Antibody-drug conjugates (ADCs) derived from interchain cysteine cross-linking demonstrate improved homogeneity and other pharmacological properties over conventional heterogeneous ADCs. Mol Pharm 12:3986–3998
5. Bouchard H, Viskov C, Garcia-Echeverria C (2014) Antibody–drug conjugates—a new wave of cancer drugs. Bioorg Med Chem Lett 24:5357–5363
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