Mechanistic conformational and substrate selectivity profiles emerging in the evolution of enzymes via parallel trajectories
Author:
Funder
Cancer Prevention and Research Institute of Texas
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41467-024-51133-y.pdf
Reference44 articles.
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2. Matsumura, I. & Patrick, W. M. Dan Tawfik’s Lessons for Protein Engineers about Enzymes Adapting to New Substrates. Biochemistry 62, 158–162 (2023).
3. Tracewell, C. A. & Arnold, F. H. Directed enzyme evolution: climbing fitness peaks one amino acid at a time. Curr. Opin. Chem. Biol. 13, 3–9 (2009).
4. Amar, D. et al. The transition of human estrogen sulfotransferase from generalist to specialist using directed enzyme evolution. J. Mol. Biol. 416, 21–32 (2012).
5. Zou, T., Risso, V. A., Gavira, J. A., Sanchez-Ruiz, J. M. & Ozkan, S. B. Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme. Mol. Biol. Evol. 32, 132–143 (2015).
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