Abstract
AbstractWe present the Danish Disease Trajectory Browser (DTB), a tool for exploring almost 25 years of data from the Danish National Patient Register. In the dataset comprising 7.2 million patients and 122 million admissions, users can identify diagnosis pairs with statistically significant directionality and combine them to linear disease trajectories. Users can search for one or more disease codes (ICD-10 classification) and explore disease progression patterns via an array of functionalities. For example, a set of linear trajectories can be merged into a disease trajectory network displaying the entire multimorbidity spectrum of a disease in a single connected graph. Using data from the Danish Register for Causes of Death mortality is also included. The tool is disease-agnostic across both rare and common diseases and is showcased by exploring multimorbidity in Down syndrome (ICD-10 code Q90) and hypertension (ICD-10 code I10). Finally, we show how search results can be customized and exported from the browser in a format of choice (i.e. JSON, PNG, JPEG and CSV).
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference54 articles.
1. Boycott, K. M. & Innes, A. M. When one diagnosis is not enough. New Engl. J. Med. 376, 83–85 (2017).
2. Blair, D. R. et al. A nondegenerate code of deleterious variants in mendelian loci contributes to complex disease risk. Cell 155, 70–80 (2013).
3. Jensen, A. B. et al. Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients. Nat. Commun. 5, 1–10 (2014).
4. Jia, G. et al. Estimating heritability and genetic correlations from large health datasets in the absence of genetic data. Nat. Commun. 10, 5508 (2019).
5. Hidalgo, C. A., Blumm, N., Barabási, A.-L. & Christakis, N. A. A dynamic network approach for the study of human phenotypes. PLoS Comput. Biol. 5, e1000353 (2009).
Cited by
79 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献