Abstract
AbstractVitellogenesis (yolk accumulation) begins upon eclosion and continues through the process of sexual maturation. Upon reaching sexual maturity, vitellogenesis is placed on hold until it is induced again by mating. However, the mechanisms that gate vitellogenesis in response to developmental and reproductive signals remain unclear. Here, we have identified the neuropeptide allatostatin-C (AstC)-producing neurons that gate both the initiation of vitellogenesis that occurs post-eclosion and its re-initiation post-mating. During sexual maturation, the AstC neurons receive excitatory inputs from Sex Peptide Abdominal Ganglion (SAG) neurons. In mature virgin females, high sustained activity of SAG neurons shuts off vitellogenesis via continuous activation of the AstC neurons. Upon mating, however, Sex Peptide inhibits SAG neurons, leading to deactivation of the AstC neurons. As a result, this permits both JH biosynthesis and the progression of vitellogenesis in mated females. Our work has uncovered a central neural circuit that gates the progression of oogenesis.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference74 articles.
1. Lin, H. The stem-cell niche theory: lessons from flies. Nat. Rev. Genet. 3, 931–940 (2002).
2. Spradling, A. C. The Development of Drosophila melanogaster (eds Bate, M., & Martinez-Arias, A.), Vol. 1, 1–70 (Cold Spring Harbor Laboratory Press, 1993).
3. Swevers, L., Raikhel, A. S., Sappington, T. W., Shirk, P. & Iatrou, K. Comprehensive Molecular Insect Science (eds Gilbert, L. I. & Iatrou, K.) Vol. 1, 87–155 (Elsevier, 2005).
4. Jowett, T. & Postlethwait, J. H. The regulation of yolk polypeptide synthesis in Drosophila ovaries and fat body by 20-hydroxyecdysone and a juvenile hormone analog. Dev. Biol. 80, 225–234 (1980).
5. Postlethwait, J. H. & Handler, A. M. The roles of juvenile hormone and 20-hydroxy-ecdysone during vitellogenesis in isolated abdomens of Drosophila melanogaster. J. Insect Physiol. 25, 455–460 (1979).
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献