Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
Author:
Funder
Wellcome Trust
Novo Nordisk Fonden
Lundbeckfonden
British Heart Foundation
Det Frie Forskningsråd
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-019-10709-9.pdf
Reference91 articles.
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2. Lakatta, E. G. & DiFrancesco, D. What keeps us ticking: a funny current, a calcium clock, or both? J. Mol. Cell Cardiol. 47, 157–170 (2009).
3. Tellez, J. O. et al. Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ. Res. 99, 1384–1393 (2006).
4. Lundby, A. et al. Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Nat. Methods 11, 868–874 (2014).
5. Lundby, A. et al. In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci. Signal. 6, rs11 (2013).
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