In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of β-Adrenergic Receptor Signaling-Reference-Cited by-同舟云学术

In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of β-Adrenergic Receptor Signaling

Published:2013-06-04 Issue:278 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Lundby Alicia¹²³,Andersen Martin N.³,Steffensen Annette B.³,Horn Heiko¹,Kelstrup Christian D.¹,Francavilla Chiara¹,Jensen Lars J.¹,Schmitt Nicole³,Thomsen Morten B.³,Olsen Jesper V.¹

Affiliation:

1. Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

2. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

3. The Danish National Research Foundation Centre for Cardiac Arrhythmia, DK-2200 Copenhagen N, Denmark.

Abstract

Analysis of phosphorylated proteins from the hearts of mice given drugs targeting β-adrenergic receptors may aid in treating heart disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference62 articles.

1. Seven-transmembrane-spanning receptors and heart function

2. Cardiac hypertrophy induced by sustained β-adrenoreceptor activation: pathophysiological aspects

3. Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol.