Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin-Reference-Cited by-同舟云学术

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

Published:2009-06-14 Issue:7 Volume:12 Page:864-871
ISSN:1097-6256
Container-title:Nature Neuroscience
language:en
Short-container-title:Nat Neurosci

Author:

Morfini Gerardo A,You Yi-Mei,Pollema Sarah L,Kaminska Agnieszka,Liu Katherine,Yoshioka Katsuji,Björkblom Benny,Coffey Eleanor T,Bagnato Carolina,Han David,Huang Chun-Fang,Banker Gary,Pigino Gustavo,Brady Scott T

Publisher

Springer Science and Business Media LLC

Subject

General Neuroscience

Link

http://www.nature.com/articles/nn.2346.pdf

Reference50 articles.

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3. Morfini, G., Pigino, G. & Brady, S.T. Polyglutamine expansion diseases: failing to deliver. Trends Mol. Med. 11, 64–70 (2005).

4. Gunawardena, S. et al. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 40, 25–40 (2003).

5. Lee, W.C., Yoshihara, M. & Littleton, J.T. Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. Proc. Natl. Acad. Sci. USA 101, 3224–3229 (2004).

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