Immunomodulatory microbial metabolites as potential predictors of stem-cell transplantation outcomes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Link
https://www.nature.com/articles/s43018-023-00670-4.pdf
Reference5 articles.
1. Peled, J. et al. Microbiota as predictor of mortality in allogeneic hematopoietic-cell transplantation. N. Eng. J. Med. 382, 822–834 (2020). This is an analysis of an international cohort that linked human microbiome to overall survival and transplantation-related mortality in allo-SCT.
2. Swimm, A. et al. lndoles derived from intestinal microbiota act via type I interferon signalling to limit graft-versus-host disease. Blood 132, 2506–2519 (2018). This paper reports that microbiota-derived indole-3-carboxaldehyde provides protection against GvHD in mouse models of allo-SCT.
3. Argelaguet, R. et al. Multi-Omics Factor Analysis — a framework for unsupervised integration of multi-omics data sets. Mol. Syst. Biol. 14, e8124 (2018). This paper describes the MOFA framework for the integration of multi-omics datasets and identification of shared features.
4. Fischer, J. C. et al. RIG-I/MAVS and STING signalling promote gut integrity during irradiation and immune-mediated tissue injury. Sci. Transl. Med. 9, eaag2513 (2017). This paper shows that activators of type I interferon signaling can positively or negatively modulate GvHD, depending on timing.
5. Michonneau, D. et al. Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites. Nat. Commun. 10, 5695 (2019). This paper was the first to perform a comprehensive untargeted analysis of the metabolome in the blood of patients receiving allo-SCT.
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