RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

Author:

Fischer Julius C.1ORCID,Bscheider Michael1ORCID,Eisenkolb Gabriel12ORCID,Lin Chia-Ching1ORCID,Wintges Alexander1ORCID,Otten Vera1,Lindemans Caroline A.34ORCID,Heidegger Simon1,Rudelius Martina5ORCID,Monette Sébastien6ORCID,Porosnicu Rodriguez Kori A.2ORCID,Calafiore Marco4ORCID,Liebermann Sophie2,Liu Chen7,Lienenklaus Stefan8ORCID,Weiss Siegfried9ORCID,Kalinke Ulrich8ORCID,Ruland Jürgen101112,Peschel Christian1ORCID,Shono Yusuke2ORCID,Docampo Melissa2ORCID,Velardi Enrico2ORCID,Jenq Robert R.4ORCID,Hanash Alan M.4,Dudakov Jarrod A.2ORCID,Haas Tobias1,van den Brink Marcel R. M.24ORCID,Poeck Hendrik12ORCID

Affiliation:

1. III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

2. Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Pediatric Blood and Bone Marrow Transplant Program, University Medical Center Utrecht, Utrecht, Netherlands.

4. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. Institute of Pathology, University of Wuerzburg and Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany.

6. Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Rockefeller University, and Weill Cornell Medical College, New York, NY 10065, USA.

7. Department of Pathology and Laboratory Medicine, New Jersey Medical School and Robert Wood Johnson Medical School, Rutgers University, Newark, NJ 08903, USA.

8. Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.

9. Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

10. Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

11. German Cancer Consortium (DKTK), Heidelberg, Germany.

12. German Center for Infection Research (DZIF), partner site Munich, Munich, Germany.

Abstract

Activation of the RIG-I or STING pathways results in a type I interferon response that protects gut integrity after irradiation- or immune-induced tissue injury.

Funder

Deutsche Forschungsgemeinschaft

Else-Kröner-Fresenius-Stiftung

Alexander von Humboldt Foundation

German Cancer Aid

European Hematology Association

NIH

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Cited by 102 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3