FoxM1 insufficiency hyperactivates Ect2–RhoA–mDia1 signaling to drive cancer-Reference-Cited by-同舟云学术

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FoxM1 insufficiency hyperactivates Ect2–RhoA–mDia1 signaling to drive cancer

Published:2020-10 Issue:10 Volume:1 Page:1010-1024
ISSN:2662-1347
Container-title:Nature Cancer
language:en
Short-container-title:Nat Cancer

Author:

Limzerwala Jazeel F.^ORCID,Jeganathan Karthik B.,Kloeber Jake A.^ORCID,Davies Brian A.,Zhang Cheng,Sturmlechner Ines,Zhong Jian^ORCID,Fierro Velasco Raul^ORCID,Fields Alan P.,Yuan Yaxia,Baker Darren J.^ORCID,Zhou Daohong^ORCID,Li Hu^ORCID,Katzmann David J.,van Deursen Jan M.^ORCID

Funder

Mayo Clinic Graduate School of Biomedical Sciences

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

https://www.nature.com/articles/s43018-020-00116-1.pdf

Reference65 articles.

1. Jaffe, A. B. & Hall, A. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247–269 (2005).

2. Olson, M. F., Ashworth, A. & Hall, A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269, 1270–1272 (1995).

3. Gerhard, R. et al. Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells. J. Med. Microbiol. 57, 765–770 (2008).

4. Provenzano, P. P. & Keely, P. J. Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. J. Cell Sci. 124, 1195–1205 (2011).

5. Haga, R. B. & Ridley, A. J. Rho GTPases: regulation and roles in cancer cell biology. Small GTPases 7, 207–221 (2016).

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1. Spatially distinct inputs modulate the amount of active Mitotic-phase GAP to locally restrict RhoA signaling for successful cell division;2023-08-09

2. FOXM1 is critical for the fitness recovery of chromosomally unstable cells;Cell Death & Disease;2023-07-14

3. Integration of Chemoinformatics and Multi-Omics Analysis Defines ECT2 as a Potential Target for Cancer Drug Therapy;Biology;2023-04-18

4. HD-PTP/PTPN23 hypomorphic mice display lipodystrophy;2022-08-03

5. In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan;Nature Aging;2022-05-05

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