A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
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Published:2021-04-26
Issue:6
Volume:2
Page:643-657
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ISSN:2662-1347
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Container-title:Nature Cancer
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language:en
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Short-container-title:Nat Cancer
Author:
Zou Xueqing, Koh Gene Ching Chiek, Nanda Arjun ScottORCID, Degasperi AndreaORCID, Urgo Katie, Roumeliotis Theodoros I., Agu Chukwuma A., Badja Cherif, Momen Sophie, Young Jamie, Amarante Tauanne Dias, Side Lucy, Brice Glen, Perez-Alonso Vanesa, Rueda DanielORCID, Gomez Celine, Bushell Wendy, Harris Rebecca, Choudhary Jyoti S.ORCID, Ambrose John C., Arumugam Prabhu, Baple Emma L., Bleda Marta, Boardman-Pretty Freya, Boissiere Jeanne M., Boustred Christopher R., Brittain Helen, Caulfield Mark J., Chan Georgia C., Craig Clare E. H., Daugherty Louise C., de Burca Anna, Devereau Andrew, Elgar Greg, Foulger Rebecca E., Fowler Tom, Furió-Tarí Pedro, Giess Adam, Hackett Joanne M., Halai Dina, Hamblin Angela, Henderson Shirley, Holman James E., Hubbard Tim J. P., ibáñez Kristina, Jackson Rob, Jones Louise J., Kasperaviciute Dalia, Kayikci Melis, Kousathanas Athanasios, Lahnstein Lea, Lawson Kay, Leigh Sarah E. A., Leong Ivonne U. S., Lopez Javier F., Maleady-Crowe Fiona, Mason Joanne, McDonagh Ellen M., Moutsianas Loukas, Mueller Michael, Murugaesu Nirupa, Need Anna C., O’Donovan Pter, Odhams Chris A., Orioli Andrea, Patch Christine, Pereira Mariana Buongermino, Perez-Gil Daniel, Polychronopoulos Dimitris, Pullinger John, Rahim Tahrima, Rendon Augusto, Riesgo-Ferreiro Pablo, Rogers Tim, Ryten Mina, Savage Kevin, Sawant Kushmita, Scott Richard H., Siddiq Afshan, Sieghart Alexander, Smedley Damian, Smith Katherine R., Smith Samuel C., Sosinsky Alona, Spooner William, Stevens Helen E., Stuckey Alexander, Sultana Razvan, Tanguy Mélanie, Thomas Ellen R. A., Thompson Simon R., Tregidgo Carolyn, Tucci Arianna, Walsh Emma, Watters Sarah A., Welland Matthew J., Williams Eleanor, Witkowska Katarzyna, Wood Suzanne M., Zarowiecki Magdalena, Jiricny Josef, Skarnes William C., Nik-Zainal SerenaORCID,
Funder
Cancer Research UK Wellcome Trust DH | National Institute for Health Research NHS England Dr Josef Steiner Cancer Research Award 2019 Medical Research Council (MRC) Grant-in-Aid to the MRC Cancer unit CRUK Pioneer Award NIHR-BRC Cambridge core grant
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Reference88 articles.
1. Helleday, T., Eshtad, S. & Nik-Zainal, S. Mechanisms underlying mutational signatures in human cancers. Nat. Rev. Genet. 15, 585–598 (2014). 2. Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415–421 (2013). 3. Nik-Zainal, S. et al. The life history of 21 breast cancers. Cell 149, 994–1007 (2012). 4. Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979–993 (2012). 5. Haradhvala, N. J. et al. Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair. Nat. Commun. 9, 1746 (2018).
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