Mechanisms underlying mutational signatures in human cancers
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg3729.pdf
Reference114 articles.
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2. Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979–993 (2012). This study presents catalogues of somatic mutations from 21 breast cancers, the respective mutational signatures of which were extracted by mathematical methods.
3. Nik-Zainal, S. et al. The life history of 21 breast cancers. Cell 149, 994–1007 (2012).
4. Bentley, D. R. et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 456, 53–59 (2008).
5. Greenman, C. et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153–158 (2007). This study shows the prevalence of somatic mutations in human cancer genomes, which indicates that most of the mutations do not drive oncogenesis. Nevertheless, it provides evidence for driver mutations that are actively involved in tumour development.
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