VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400-Reference-Cited by-同舟云学术

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VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

Published:2008-02-24 Issue:3 Volume:10 Page:361-369
ISSN:1465-7392
Container-title:Nature Cell Biology
language:en
Short-container-title:Nat Cell Biol

Author:

Young Arthur P.,Schlisio Susanne,Minamishima Yoji Andrew,Zhang Qing,Li Lianjie,Grisanzio Chiara,Signoretti Sabina,Kaelin William G.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Link

http://www.nature.com/articles/ncb1699.pdf

Reference33 articles.

1. Kaelin, W. G. Jr. Von Hippel–Lindau disease. Annu. Rev. Pathol. 2, 145–173.

2. Patil, C. K., Mian, I. S. & Campisi, J. The thorny path linking cellular senescence to organismal aging. Mech. Ageing Dev. 126, 1040–1045 (2005).

3. Lowe, S. W., Cepero, E. & Evan, G. Intrinsic tumour suppression. Nature 432, 307–315 (2004).

4. Di Leonardo, A., Linke, S. P., Clarkin, K. & Wahl, G. M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540–2551 (1994).

5. Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725–730 (2005).

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