Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor-Reference-Cited by-同舟云学术

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

Published:2016-07-11 Issue:9 Volume:12 Page:709-716
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Kahsai Alem W,Wisler James W,Lee Jungmin,Ahn Seungkirl,Cahill III Thomas J,Dennison S Moses,Staus Dean P,Thomsen Alex R B,Anasti Kara M,Pani Biswaranjan,Wingler Laura M,Desai Hemant,Bompiani Kristin M,Strachan Ryan T,Qin Xiaoxia,Alam S Munir,Sullenger Bruce A,Lefkowitz Robert J

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.2126.pdf

Reference54 articles.

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3. Lagerström, M.C. & Schiöth, H.B. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat. Rev. Drug Discov. 7, 339–357 (2008).

4. Kobilka, B.K. Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor. Anal. Biochem. 231, 269–271 (1995).

5. Rajagopal, S., Rajagopal, K. & Lefkowitz, R.J. Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat. Rev. Drug Discov. 9, 373–386 (2010).

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