Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α-Reference-Cited by-同舟云学术

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Published:2010-10-03 Issue:11 Volume:6 Page:829-836
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Thorne Curtis A,Hanson Alison J,Schneider Judsen,Tahinci Emilios,Orton Darren,Cselenyi Christopher S,Jernigan Kristin K,Meyers Kelly C,Hang Brian I,Waterson Alex G,Kim Kwangho,Melancon Bruce,Ghidu Victor P,Sulikowski Gary A,LaFleur Bonnie,Salic Adrian,Lee Laura A,Miller David M,Lee Ethan

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.453.pdf

Reference50 articles.

1. Yamamoto, H. et al. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability. J. Biol. Chem. 274, 10681–10684 (1999).

2. Tolwinski, N.S. et al. Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Dev. Cell 4, 407–418 (2003).

3. Kofron, M. et al. Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin. Development 134, 503–513 (2007).

4. Cselenyi, C.S. et al. LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin. Proc. Natl. Acad. Sci. USA 105, 8032–8037 (2008).

5. Barker, N. & Clevers, H. Mining the Wnt pathway for cancer therapeutics. Nat. Rev. Drug Discov. 5, 997–1014 (2006).

Cited by 427 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Phytochemicals as Potential Lead Molecules against Hepatocellular Carcinoma;Current Medicinal Chemistry;2024-10

2. Wnt/β-catenin signalling underpins juvenileFasciola hepaticagrowth and development;2024-09-07

3. Targeting the Wnt/β-catenin signal pathway for the treatment of gastrointestinal cancer: Potential for advancement;Biochemical Pharmacology;2024-09

4. Mechanistic insights into medulloblastoma relapse;Pharmacology & Therapeutics;2024-08

5. Blocking the WNT/β-catenin pathway in cancer treatment:pharmacological targets and drug therapeutic potential;Heliyon;2024-08