Mining the Wnt pathway for cancer therapeutics
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2154.pdf
Reference200 articles.
1. Tetsu, O. & McCormick, F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422–426 (1999).
2. van de Wetering, M. et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241–250 (2002). Reports the identification of the Tcf target gene program that is inappropriately activated in colon cancer cells displaying aberrant Wnt signalling activity. Together with reference 1 this also conclusively demonstrates that blockade of this Wnt signalling activity effectively inhibits cancer cell growth in vitro.
3. Van der Flier, L. et al. The intestinal Wnt signature. Gastroenterology (in the press).
4. Logan, C. Y. & Nusse, R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781–810 (2004).
5. Kinzler, K. W. et al. Identification of FAP locus genes from chromosome 5q21. Science 253, 661–665 (1991).
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