A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans-Reference-Cited by-同舟云学术

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A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

Published:2010-05-30 Issue:7 Volume:6 Page:549-557
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Burns Andrew R,Wallace Iain M,Wildenhain Jan,Tyers Mike,Giaever Guri,Bader Gary D,Nislow Corey,Cutler Sean R,Roy Peter J

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.380.pdf

Reference43 articles.

1. Burns, A.R. et al. High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans. Nat. Protoc. 1, 1906–1914 (2006).

2. Kwok, T.C.Y. et al. A small-molecule screen in C. elegans yields a new calcium channel antagonist. Nature 441, 91–95 (2006).

3. Petrascheck, M., Ye, X. & Buck, L.B. An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 450, 553–556 (2007).

4. Kokel, D., Li, Y., Qin, J. & Xue, D. The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans. Nat. Chem. Biol. 2, 338–345 (2006).

5. Kwok, T.C. et al. A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels. PLoS Genet. 4, e1000067 (2008).

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