High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans-Reference-Cited by-同舟云学术

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High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans

Published:2006-11 Issue:4 Volume:1 Page:1906-1914
ISSN:1754-2189
Container-title:Nature Protocols
language:en
Short-container-title:Nat Protoc

Author:

Burns Andrew R,Kwok Trevor C Y,Howard Al,Houston Ed,Johanson Karl,Chan Anthony,Cutler Sean R,McCourt Peter,Roy Peter J

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology

Link

http://www.nature.com/articles/nprot.2006.283.pdf

Reference27 articles.

1. Stockwell, B.R. Exploring biology with small organic molecules. Nature 432, 846–854 (2004).

2. Kwok, T.C. et al. A small-molecule screen in C. elegans yields a new calcium channel antagonist. Nature 441, 91–95 (2006).

3. Lackner, M.R. et al. Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell 7, 325–336 (2005).

4. Kokel, D., Li, Y., Qin, J. & Xue, D. The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans. Nat. Chem. Biol. 2, 338–345 (2006).

5. Weinshenker, D., Garriga, G. & Thomas, J.H. Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans. J. Neurosci. 15, 6975–6985 (1995).

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