Regulation of the oncoprotein Smoothened by small molecules
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nchembio.1776.pdf
Reference100 articles.
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2. Amakye, D., Jagani, Z. & Dorsch, M. Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat. Med. 19, 1410–1422 (2013).
3. Stone, D.M. et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129–134 (1996).
4. Izzi, L. et al. Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev. Cell 20, 788–801 (2011).
5. Taipale, J., Cooper, M.K., Maiti, T. & Beachy, P.A. Patched acts catalytically to suppress the activity of Smoothened. Nature 418, 892–897 (2002).
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