Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Cancer Research,Hematology
Link
http://www.nature.com/articles/2403560.pdf
Reference25 articles.
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3. Shah N, Oseth L, LeBien TW . Development of a model for evaluating the interaction between human pre-B acute lymphoblastic leukemic cells and the bone marrow stromal cell microenvironment. Blood 1998; 92: 3817–3828.
4. Vega F, Medeiros LJ, Lang W-H, Mansoor A, Bueso-Ramos C, Jone D . The stomal composition of malignant lymphoid aggregates in bone marrow: variations in architecture and phenotype in different B-cell tumours. Br J Haematol 2002; 117: 569–576.
5. Burger JA, Tsukada N, Burger M, Zvailfler NK, Dell'Aquila M, Kipps TJ . Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell derived factor-1. Blood 2002; 96: 2655–2663.
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