Activation of WNT/β-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboringPIK3CAmutations-Reference-Cited by-同舟云学术

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Activation of WNT/β-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboringPIK3CAmutations

Published:2018-11-29 Issue:2 Volume:144 Page:389-401
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Int. J. Cancer

Author:

Park Ye-Lim¹²,Kim Hwang-Phill¹²^ORCID,Cho Young-Won¹²,Min Dong-Wook¹²,Cheon Seul-Ki¹²,Lim Yoo Joo³,Song Sang-Hyun²,Kim Sung Jin⁴,Han Sae-Won²³,Park Kyu Joo⁵,Kim Tae-You¹²³

Affiliation:

1. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology; Seoul National University; Seoul South Korea

2. Cancer Research Institute; Seoul National University; Seoul South Korea

3. Department of Internal Medicine; Seoul National University Hospital; Seoul South Korea

4. Department of Biochemistry and Molecular Biology; Pennsylvania State University; University Park PA

5. Department of Surgery; Seoul National University College of Medicine; Seoul South Korea

Funder

Ministry of Education of the Republic of Korea

The Ministry of Health & Welfare, Republic of Korea

The Ministry of Science, ICT & Future Planning, Republic of Korea

National Research Foundation of Korea

Publisher

Wiley

Subject

Cancer Research,Oncology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/ijc.31662/fullpdf

Reference51 articles.

1. PI3K-AKT-mTOR pathway and cancer;Coutte;Bull Cancer,2012

2. PI3K pathway alterations in cancer: variations on a theme;Yuan;Oncogene,2008

3. A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas;Rudd;Clin Cancer Res,2011

4. Targeting the phosphoinositide 3-kinase pathway in cancer;Liu;Nat Rev Drug Discov,2009

5. The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients;Martelli;Oncotarget,2010

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