Genomic gain at 6p21: a new cryptic molecular rearrangement in secondary myelodysplastic syndrome and acute myeloid leukemia

Author:

La Starza R,Aventin A,Matteucci C,Crescenzi B,Romoli S,Testoni N,Pierini V,Ciolli S,Sambani C,Locasciulli A,Di Bona E,Lafage-Pochitaloff M,Martelli M F,Marynen P,Mecucci C

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference40 articles.

1. Soekarman D, von Lindern M, Daenen S, de Jong B, Fonatch C, Heinze B et al. The translocation (6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features. Blood 1992; 79: 2990–2997.

2. Oyarzo MP, Lin P, Glassman A, Bueso-Ramos CE, Luthra R, Medeiros J . Acute myeloid leukemia with t(6;9)(p23;q34) is associated with dysplasia and a high frequency of FLT3 mutations. Hematopathology 2004; 122: 348–358.

3. Akasaka T, Miura I, Takahashi N, Akasaka H, Yonetani N, Ohno H et al. A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5′ regulatory region of BCL-6 with a novel H4 histone gene. Cancer Res 1997; 57: 7–12.

4. Chen W, Itoyama T, Chaganti RSK . Splicing factor SRP20 is a novel partner of BCL6 in a t(3;6)(q27;p21) translocation in transformed follicular lymphoma. Genes Chromosome Cancer 2001; 32: 281–284.

5. Sonoki T, Harder L, Horsman DE, Karran L, Taniguchi I, Willis TG et al. Cyclin D3 is a target of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood 2001; 98: 2837–2844.

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