Abstract
AbstractPositronium (Ps), a hydrogen-like atom consisting of a positron and an electron, is efficiently formed in the human body during positron emission tomography (PET) examination, and its decay rate into gamma-ray photons is significantly influenced by the chemical environment, especially the dissolved oxygen concentration (pO2) due to the unpaired electrons. However, the functionality of PET has been underestimated by neglecting the specific information provided by Ps. By comparing the decay rates in O2-, N2-, and air-saturated waters, here we show that Ps probes the absolute value of pO2 with a good linearity and a resolution better than 10 mmHg. This is a sufficient sensitivity for discriminating a hypoxic region in a tumor at approximately 6 mmHg from healthy tissues at approximately 40 mmHg. This method depends only on the fundamental properties of Ps and is independent of specific radiopharmaceuticals. The applications of Ps spin states and reactions will greatly enhance PET functionalities in the next decade.
Funder
MEXT | Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Whole Gamma Imaging;PET Clinics;2024-01
2. Cross-sections and gamma-yields in (p, x) reactions on 14N and 16O for 14,15O production;Bio-Algorithms and Med-Systems;2023-12-31
3. Estimating influence of positron range in proton-therapy-beam monitoring with PET;Bio-Algorithms and Med-Systems;2023-12-31
4. Modeling Positronium Lifetime Distribution in Geant4 Monte Carlo Simulation;2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD);2023-11-04
5. Positronium Lifetime Measurements using 82Rb in a Long-Axial FOV PET/CT Scanner;2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD);2023-11-04