Positronium image of the human brain in vivo-Reference-Cited by-同舟云学术

Positronium image of the human brain in vivo

Published:2024-09-13 Issue:37 Volume:10 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Moskal Paweł¹²^ORCID,Baran Jakub¹²^ORCID,Bass Steven¹²³,Choiński Jarosław⁴^ORCID,Chug Neha¹²^ORCID,Curceanu Catalina⁵^ORCID,Czerwiński Eryk¹²^ORCID,Dadgar Meysam¹²^ORCID,Das Manish¹²^ORCID,Dulski Kamil¹²^ORCID,Eliyan Kavya V.¹²^ORCID,Fronczewska Katarzyna⁶^ORCID,Gajos Aleksander¹²^ORCID,Kacprzak Krzysztof¹²^ORCID,Kajetanowicz Marcin¹²,Kaplanoglu Tevfik¹²^ORCID,Kapłon Łukasz¹²^ORCID,Klimaszewski Konrad⁷^ORCID,Kobylecka Małgorzata⁶,Korcyl Grzegorz¹²^ORCID,Kozik Tomasz¹²,Krzemień Wojciech¹²⁸^ORCID,Kubat Karol¹²^ORCID,Kumar Deepak¹²^ORCID,Kunikowska Jolanta⁶^ORCID,Mączewska Joanna⁶,Migdał Wojciech¹²,Moskal Gabriel²⁹^ORCID,Mryka Wiktor¹²^ORCID,Niedźwiecki Szymon¹²^ORCID,Parzych Szymon¹²,del Rio Elena P.¹²^ORCID,Raczyński Lech⁷^ORCID,Sharma Sushil¹²,Shivani Shivani¹²,Shopa Roman Y.⁷^ORCID,Silarski Michał¹²^ORCID,Skurzok Magdalena¹²,Tayefi Faranak¹²^ORCID,Ardebili Keyvan T.¹²^ORCID,Tanty Pooja¹²^ORCID,Wiślicki Wojciech⁷^ORCID,Królicki Leszek⁶^ORCID,Stępień Ewa Ł.¹²^ORCID

Affiliation:

1. Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.

2. Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.

3. Kitzbühel Centre for Physics, Kitzbühel, Austria.

4. Heavy Ion Laboratory, University of Warsaw, Warsaw, Poland.

5. INFN, Laboratori Nazionali di Frascati, Via E. Fermi 40, 00044 Frascati, Italy.

6. Department of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.

7. Department of Complex Systems, National Centre for Nuclear Research, 05-400 Otwock-Świerk, Poland.

8. High Energy Department, National Centre for Nuclear Research, 05-400 Otwock-Świerk, Poland.

9. Department of Chemical Technology, Faculty of Chemistry of the Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.

Abstract

Positronium is abundantly produced within the molecular voids of a patient’s body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen. Current PET systems record only two annihilation photons and cannot provide information about the positronium lifetime. This study presents the in vivo images of positronium lifetime in a human, for a patient with a glioblastoma brain tumor, by using the dedicated Jagiellonian PET system enabling simultaneous detection of annihilation photons and prompt gamma emitted by a radionuclide. The prompt gamma provides information on the time of positronium formation. The photons from positronium annihilation are used to reconstruct the place and time of its decay. In the presented case study, the determined positron and positronium lifetimes in glioblastoma cells are shorter than those in salivary glands and those in healthy brain tissues, indicating that positronium imaging could be used to diagnose disease in vivo.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adp2840

Reference85 articles.

1. Positronium in medicine and biology

2. Colloquium : Positronium physics and biomedical applications

3. Positronium as a biomarker of hypoxia;Moskal P.;Bioalgorithms Medsystem,2021

4. Oxygen sensing ability of positronium atom for tumor hypoxia imaging

5. 3D melanoma spheroid model for the development of positronium biomarkers