Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study
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Published:2023-04-17
Issue:1
Volume:9
Page:
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ISSN:2373-8057
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Container-title:npj Parkinson's Disease
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language:en
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Short-container-title:npj Parkinsons Dis.
Author:
Adams Jamie L.ORCID, Kangarloo Tairmae, Tracey BrianORCID, O’Donnell PatricioORCID, Volfson Dmitri, Latzman Robert D.ORCID, Zach Neta, Alexander Robert, Bergethon Peter, Cosman Joshua, Anderson David, Best AllenORCID, Severson Joan, Kostrzebski Melissa A., Auinger Peggy, Wilmot Peter, Pohlson Yvonne, Waddell EmmaORCID, Jensen-Roberts Stella, Gong YishuORCID, Kilambi Krishna PraneethORCID, Herrero Teresa Ruiz, Ray Dorsey E.ORCID, Adams Jamie L., Tarolli Christopher, Waddell Emma, Jensen-Roberts Stella, Soto Julia, Hogarth Penelope, Wahedi Mastura, Wakeman Katrina, Espay Alberto J., Brown Julia, Wurzelbacher Christina, Gunzler Steven A., Khawam Elisar, Kilbane Camilla, Spindler Meredith, Engeland Megan, Tarakad Arjun, Barrett Matthew J., Cloud Leslie J., Norris Virginia, Mari Zoltan, Wyant Kara J., Chou Kelvin, Stovall Angela, Poon Cynthia, Simuni Tanya, Tingling Kyle, Luthra Nijee, Tanner Caroline, Yilmaz Eda, Romero Danilo, Thomas Karen, Matson Leslie, Richardson Lisa, Fullard Michelle, Feuerstein Jeanne, Shelton Erika, Shprecher David, Callan Michael, Feigin Andrew, Romano Caitlin, Romain Martina, Shum Michelle, Botting Erica, Harrell Leigh, Rocha Claudia, Ramdhani Ritesh, Gardner Joshua, Parker Ginger, Ross Victoria, Stephen Steve, Fisher Katherine, Edgerton Jeremy, Cedarbaum Jesse, Rubens Robert, Padmanabhan Jaya, Stephenson Diane, Severson Brian, Merickel Michael, Amato Daniel Jackson, Carroll Thomas,
Abstract
AbstractDigital health technologies can provide continuous monitoring and objective, real-world measures of Parkinson’s disease (PD), but have primarily been evaluated in small, single-site studies. In this 12-month, multicenter observational study, we evaluated whether a smartwatch and smartphone application could measure features of early PD. 82 individuals with early, untreated PD and 50 age-matched controls wore research-grade sensors, a smartwatch, and a smartphone while performing standardized assessments in the clinic. At home, participants wore the smartwatch for seven days after each clinic visit and completed motor, speech and cognitive tasks on the smartphone every other week. Features derived from the devices, particularly arm swing, the proportion of time with tremor, and finger tapping, differed significantly between individuals with early PD and age-matched controls and had variable correlation with traditional assessments. Longitudinal assessments will inform the value of these digital measures for use in future clinical trials.
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology (clinical),Neurology
Reference56 articles.
1. GBD 2015 Neurological Disorders Collaborator Group. Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol. 16, 877–897 (2017). 2. Dorsey, E. R., Sherer, T., Okun, M. S. & Bloem, B. R. Ending Parkinson’s Disease: A Prescription for Action. (PublicAffairs, 2020). 3. Simuni, T. et al. Longitudinal change of clinical and biological measures in early Parkinson’s disease: Parkinson’s Progression Markers Initiative cohort. Mov. Disord. 33, 771–782 (2018). 4. Dorsey, E. R., Papapetropoulos, S., Xiong, M. & Kieburtz, K. The first frontier: digital biomarkers for neurodegenerative disorders. Digital Biomark. 1, 6–13 (2017). 5. Post, B., Merkus, M. P., de Bie, R. M. A., de Haan, R. J. & Speelman, J. D. Unified Parkinson’s disease rating scale motor examination: are ratings of nurses, residents in neurology, and movement disorders specialists interchangeable? Mov. Disord. 20, 1577–1584 (2005).
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