Abstract
AbstractUveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.
Funder
U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
Computer Science Applications,History,Education
Cited by
12 articles.
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