Apoptosis subversion: HIV-Nef provides both armor and sword
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm1101-1181.pdf
Reference15 articles.
1. Wolf, D. et al. Nef-associated PAK and PI3-kinases stimulate Bad phosphorylation in an Akt-independent pathway. Implications for anti-apoptosis signaling in HIV-infected cells. Nature Med. 7, 1217–1224 (2001).
2. Geleziunas, R., Xu, W., Takeda, K., Ichijo, H. & Greene, W.C. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature 410, 834–838 (2001).
3. Badley, A.D., Pilon, A.A., Landay, A. & Lynch, D.H. Mechanisms of HIV-associated lymphocyte apoptosis. Blood 96, 2951–2964 (2000).
4. Zauli, G. et al. Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway. Blood 93, 1000–1010 (1999).
5. Xu, X.N. et al. Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor ζ chain. J. Exp. Med. 189, 1489–1496 (1999).
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