Multiscale Kinetic Modeling of Liposomal Doxorubicin Delivery Quantifies the Role of Tumor and Drug-Specific Parameters in Local Delivery to Tumors

Author:

Hendriks BS1,Reynolds JG1,Klinz SG1,Geretti E1,Lee H1,Leonard SC1,Gaddy DF1,Espelin CW1,Nielsen UB1,Wickham TJ1

Affiliation:

1. Merrimack Pharmaceuticals; Cambridge Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

Reference50 articles.

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3. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (Caelyx/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer;O'Brien;Ann. Oncol.,2004

4. Significant increase in antitumor potency of doxorubicin Hc1 by its encapsulation in pegylated liposomes;Colbern;J. Liposome Res.,1999

5. Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial?;Hong;Clin. Cancer Res.,1999

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