PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Molecular Biology
Link
http://www.nature.com/articles/1210290.pdf
Reference28 articles.
1. Ahn JY, Hu Y, Kroll TG, Allard P, Ye K . (2004a). PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc Natl Acad Sci USA 101: 6993–6998.
2. Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K . (2004b). PIKE (Phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. J Biol Chem 279: 16441–16451.
3. Ahn JY, Rong R, Liu X, Ye K . (2004c). PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus. EMBO J 23: 3995–4006.
4. Bellacosa A, Testa JR, Staal SP, Tsichlis PN . (1991). A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254: 274–277.
5. Brazil DP, Park J, Hemmings BA . (2002). PKB binding proteins. Getting in on the Akt. Cell 111: 293–303.
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