Author:
Sun Wenhuizi,Huang Runzhi,Li Zhenyu,Zhu Yaru,Bai Yan,Wu Siyu,Wang Jingshuai,Xiao Yan,Xian Shuyuan,Tong Xiaowen,Zhang Jie,Guo Yi,Ouyang Yiqin
Abstract
AbstractAlternative splicing (AS) is common in gene expression, and abnormal splicing often results in several cancers. Overall survival-associated splicing events (OS-SEs) have been used to predict prognosis in cancer. The aim of this study was to investigate the presence and function of OS-SEs in uterine corpus endometrial carcinoma (UCEC). Based on TCGA and TCGASpliceSeq databases, gene expression and the AS data of UCEC samples were retrieved. An alternate terminator of ANKHD1 transcripts named ANKHD1-BP3 was found to be significantly related to metastasis and OS in UCEC and significantly associated with HSPB1. The upregulated expression of HSPB1 induced downregulation of ANKHD1-BP3 and promoted tumor metastasis. These findings indicate that HSPB1, a splicing factor, regulates the expression of ANKHD1-BP3 to promote metastasis in UCEC.
Funder
National Natural Science Foundation of China
Youth Fund of the National Natural Science Fund projec
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
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