MHC-II heterozygosity limits type 1 diabetes susceptibility through negative selection
Author:
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy
Link
https://www.nature.com/articles/s41590-023-01446-9.pdf
Reference5 articles.
1. Huseby, E. S. & Teixeiro, E. The perception and response of T cells to a changing environment are based on the law of initial value. Sci. Signal. 15, eabj9842 (2022). A review article that highlights the role of self-peptide MHC recognition in T cell development.
2. Todd, J. A. et al. A molecular basis for MHC class II-associated autoimmunity. Science 240, 1003–1009 (1988). This paper reports that MHC-II polymorphisms influence T1D susceptibility.
3. Hu, X. et al. Additive and interaction effects at three amino acid position in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nat. Genet. 47, 898–905 (2015). This paper reports that homozygous expression of MHC-II susceptibility alleles increases T1D risk.
4. Stadinski, B., Kappler, J. & Eisenbarth, G. S. Molecular targeting of islet autoantigens. Immunity 32, 446–456 (2010). A review article that presents the role of T cells and autoantigens in the T1D disease process.
5. Stadinski, B. D. et al. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nat. Immunol. 17, 946–955 (2016). A paper that reports global changes in TCR CDR3 usage by self-reactive T cells.
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