Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
http://www.nature.com/articles/ng.3353.pdf
Reference37 articles.
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2. Raychaudhuri, S. et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat. Genet. 44, 291–296 (2012).
3. Trynka, G., Wijmenga, C. & van Heel, D.A. A genetic perspective on coeliac disease. Trends Mol. Med. 16, 537–550 (2010).
4. Gourraud, P.A., Harbo, H.F., Hauser, S.L. & Baranzini, S.E. The genetics of multiple sclerosis: an up-to-date review. Immunol. Rev. 248, 87–103 (2012).
5. Lee, K.H., Wucherpfennig, K.W. & Wiley, D.C. Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2, 501–507 (2001).
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