PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity-Reference-Cited by-同舟云学术

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

Published:2019-09-16 Issue:10 Volume:20 Page:1335-1347
ISSN:1529-2908
Container-title:Nature Immunology
language:en
Short-container-title:Nat Immunol

Author:

LaFleur Martin W.,Nguyen Thao H.^ORCID,Coxe Matthew A.,Miller Brian C.,Yates Kathleen B.^ORCID,Gillis Jacob E.,Sen Debattama R.,Gaudiano Emily F.,Al Abosy Rose^ORCID,Freeman Gordon J.,Haining W. Nicholas^ORCID,Sharpe Arlene H.^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Link

http://www.nature.com/articles/s41590-019-0480-4.pdf

Reference57 articles.

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2. Wherry, E. J. T cell exhaustion. Nat. Immunol. 12, 492–499 (2011).

3. Baitsch, L. et al. Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients. J. Clin. Invest. 121, 2350–2360 (2011).

4. Miller, B. C. et al. Subsets of exhausted CD8(+) T cells differentially mediate tumor control and respond to checkpoint blockade. Nat. Immunol. 20, 326–336 (2019).

5. Wherry, E. J., Blattman, J. N., Murali-Krishna, K., van der Most, R. & Ahmed, R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77, 4911–4927 (2003).

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