Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Materials Chemistry,Biochemistry,Environmental Chemistry,General Chemistry
Link
http://www.nature.com/articles/s42004-019-0174-8.pdf
Reference23 articles.
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3. Wainberg, M. A., Zaharatos, G. J. & Brenner, B. G. Development of antiretroviral drug resistance. New Engl. J. Med. 365, 637–646 (2011).
4. Lehman, D. A. et al. Low-frequency nevirapine resistance at multiple sites may predict treatment failure in infants on nevirapine-based treatment. J. Acquir. immune Defic. Syndr. 60, 225–233 (2012).
5. Beyrer, C. & Pozniak, A. HIV drug resistance - an emerging threat to epidemic control. New Engl. J. Med. 377, 1605–1607 (2017).
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