In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase-Reference-Cited by-同舟云学术

In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase

Published:2001-10 Issue:20 Volume:8 Page:1547-1554
ISSN:0969-7128
Container-title:Gene Therapy
language:en
Short-container-title:Gene Ther

Author:

Chung-Faye GA,Chen MJ,Green NK,Burton A,Anderson D,Mautner V,Searle PF,Kerr DJ

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.nature.com/articles/3301557.pdf

Reference16 articles.

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2. Douillard JY et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial (published erratum appears in Lancet 2000 Apr 15;355(9212):1372) Lancet 2000 355: 1041–1047

3. Mullen CA, Kilstrup M, Blaese RM . Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system Proc Nat Acad Sci USA 1992 89: 33–37

4. Austin EA, Huber BE . A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase Mol Pharm 1993 43: 380–387

5. Hirschowitz EA et al. In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine Hum Gene Ther 1995 6: 1055–1063

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