Plasmid-electroporated primary hepatocytes acquire quasi-physiological secretion of human insulin and restore euglycemia in diabetic mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
http://www.nature.com/articles/3302446.pdf
Reference28 articles.
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2. Thule PM, Liu JM . Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Therapy 2000; 7: 1744–1752.
3. Tuch BE et al. Function of a genetically modified human liver cell line that stores, processes and secretes insulin. Gene Therapy 2003; 10: 490–503.
4. Falqui L et al. Reversal of diabetes in mice by implantation of human fibroblasts genetically engineered to release mature human insulin. Hum Gene Ther 1999; 10: 1753–1762.
5. Liu Q, Muruve DA . Molecular basis of the inflammatory response to adenovirus vectors. Gene Therapy 2003; 10: 935–940.
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