Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing-Reference-Cited by-同舟云学术

Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

Published:2018-03-09 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Weng Yan,Ishino Tetsuya,Sievers Annette,Talukdar Saswata,Chabot Jeffrey R.,Tam Amy,Duan Weili,Kerns Kelvin,Sousa Eric,He Tao,Logan Alison,Lee Darwin,Li Dongmei,Zhou Yingjiang,Bernardo Barbara,Joyce Alison,Kavosi Mania,O’Hara Denise M.,Clark Tracey,Guo Jie,Giragossian Craig,Stahl Mark,Calle Roberto A.^ORCID,Kriz Ron,Somers Will,Lin Laura

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-22456-w.pdf

Reference58 articles.

1. Kharitonenkov, A. et al. FGF-21 as a novel metabolic regulator. The Journal of clinical investigation 115, 1627–1635, https://doi.org/10.1172/JCI23606 (2005).

2. Beenken, A. & Mohammadi, M. The FGF family: biology, pathophysiology and therapy. Nature reviews. Drug discovery 8, 235–253, https://doi.org/10.1038/nrd2792 (2009).

3. Ding, X. et al. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell metabolism 16, 387–393, https://doi.org/10.1016/j.cmet.2012.08.002 (2012).

4. Foltz, I. N. et al. Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex. Science translational medicine 4, 162ra153, https://doi.org/10.1126/scitranslmed.3004690 (2012).

5. Kharitonenkov, A. et al. FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho. Journal of cellular physiology 215, 1–7, https://doi.org/10.1002/jcp.21357 (2008).

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