Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex-Reference-Cited by-同舟云学术

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex

Published:2012-11-28 Issue:162 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Foltz Ian N.¹,Hu Sylvia²,King Chadwick¹,Wu Xinle³,Yang Chaofeng⁴,Wang Wei²,Weiszmann Jennifer³,Stevens Jennitte²,Chen Jiyun Sunny³,Nuanmanee Noi²,Gupte Jamila³,Komorowski Renee²,Sekirov Laura¹,Hager Todd²,Arora Taruna²,Ge Hongfei³,Baribault Helene³,Wang Fen⁴,Sheng Jackie²,Karow Margaret²,Wang Minghan²,Luo Yongde⁴,McKeehan Wallace⁴,Wang Zhulun³,Véniant Murielle M.²,Li Yang³

Affiliation:

1. Amgen British Columbia, 7990 Enterprise Street, Burnaby, British Columbia V5A1V7, Canada.

2. Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

3. Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

4. Texas A&M Health Science Center, 2121 West Holcombe Boulevard, 520B, Houston, TX 77030, USA.

Abstract

A monoclonal antibody mimic of FGF21 exerts beneficial metabolic effects in obese monkeys.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

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5. Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

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