Author:
Navandar Mohit,Martín-García Elena,Maldonado Rafael,Lutz Beat,Gerber Susanne,Ruiz de Azua Inigo
Abstract
AbstractAddiction is a chronic relapsing brain disease characterized by compulsive reward-seeking despite harmful consequences. The mechanisms underlying addiction are orchestrated by transcriptional reprogramming in the reward system of vulnerable subjects. This study aims at revealing gene expression alterations across different types of addiction. We analyzed publicly available transcriptome datasets of the prefrontal cortex (PFC) from a palatable food and a cocaine addiction study. We found 56 common genes upregulated in the PFC of addicted mice in these two studies, whereas most of the differentially expressed genes were exclusively linked to either palatable food or cocaine addiction. Gene ontology analysis of shared genes revealed that these genes contribute to learning and memory, dopaminergic synaptic transmission, and histone phosphorylation. Network analysis of shared genes revealed a protein–protein interaction node among the G protein-coupled receptors (Drd2, Drd1, Adora2a, Gpr6, Gpr88) and downstream targets of the cAMP signaling pathway (Ppp1rb1, Rgs9, Pde10a) as a core network in addiction. Upon extending the analysis to a cell-type specific level, some of these common molecular players were selectively expressed in excitatory neurons, oligodendrocytes, and endothelial cells. Overall, computational analysis of publicly available whole transcriptome datasets provides new insights into the molecular basis of addiction-like behaviors in PFC.
Funder
Fundació la Marató de TV3
Ministerio de Sanidad, Servicios Sociales e Igualdad
Ministerio de Ciencia, Innovación y Universidades
Instituto de Salud Carlos III
Generalitat de Catalunya
Boehringer Ingelheim Stiftung
Carl-Zeiss-Stiftung
Mainz Institute of Multiscale Modeling- M3odel
Leibniz-Institut für Resilienzforschung (LIR)
Publisher
Springer Science and Business Media LLC
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献