Author:
Miglar Aurelie,Reuling Isaie J.,Yap Xi Zen,Färnert Anna,Sauerwein Robert W.,Asghar Muhammad
Abstract
AbstractCellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection.
Funder
PATH Malaria Vaccine Initiative Funds
Ragnar Söderbergs stiftelse
Vetenskapsrådet
Svenska Sällskapet för Medicinsk Forskning
Stiftelsen Sigurd och Elsa Goljes Minne
Karolinska Institutet Funds and Foundation
Karolinska Institute
Publisher
Springer Science and Business Media LLC
Cited by
8 articles.
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