Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing-Reference-Cited by-同舟云学术

Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing

Published:2019-01-28 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Vautrin Audrey,Manchon Laurent,Garcel Aude,Campos Noëlie,Lapasset Laure,Laaref Abdelhamid Mahdi,Bruno Roman,Gislard Marie,Dubois Emeric^ORCID,Scherrer Didier,Ehrlich J Hartmut,Tazi Jamal

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-37813-y.pdf

Reference66 articles.

1. Chebli, K. et al. The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages. Sci Rep 7, 4860 (2017).

2. Campos, N. et al. Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis. Retrovirology 12, 30 (2015).

3. Gonatopoulos-Pournatzis, T. & Cowling, V. H. Cap-binding complex (CBC). Biochem. J. 457, 231–242 (2014).

4. Izaurralde, E. et al. A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell 78, 657–668 (1994).

5. Pabis, M. et al. The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells. RNA 19, 1054–1063 (2013).

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