Upregulation of microRNA-96-5p is associated with adolescent idiopathic scoliosis and low bone mass phenotype

Author:

Chen Huanxiong,Yang Kenneth Guangpu,Zhang Jiajun,Cheuk Ka-yee,Nepotchatykh Evguenia,Wang Yujia,Hung Alec Lik-hang,Lam Tsz-ping,Moreau Alain,Lee Wayne Yuk-wai

Abstract

AbstractBone densitometry revealed low bone mass in patients with adolescent idiopathic scoliosis (AIS) and its prognostic potential to predict curve progression. Recent studies showed differential circulating miRNAs in AIS but their diagnostic potential and links to low bone mass have not been well-documented. The present study aimed to compare miRNA profiles in bone tissues collected from AIS and non-scoliotic subjects, and to explore if the selected miRNA candidates could be useful diagnostic biomarkers for AIS. Microarray analysis identified miR-96-5p being the most upregulated among the candidates. miR-96-5p level was measured in plasma samples from 100 AIS and 52 healthy girls. Our results showed significantly higher plasma levels of miR-96-5p in AIS girls with an area under the curve (AUC) of 0.671 for diagnostic accuracy. A model that was composed of plasma miR-96-5p and patient-specific parameters (age, body weight and years since menarche) gave rise to an improved AUC of 0.752. Ingenuity Pathway Analysis (IPA) indicated functional links between bone metabolic pathways and miR-96-5p. In conclusion, differentially expressed miRNAs in AIS bone and plasma samples represented a new source of disease biomarkers and players in AIS etiopathogenesis, which required further validation study involving AIS patients of both genders with long-term follow-up.

Funder

National Natural Science Foundation of China

Young Talents’ Science and Technology Innovation Project of Hainan Association for Science and Technology

The Cotrel Foundation at Institut de France

Research Grants Council of the Hong Kong S.A.R.

Health and Medical Research Fund

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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