Affiliation:
1. Department of Spine Surgery and Orthopedics Xiangya Hospital, Central South University Changsha Hunan P.R. China
2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan P.R. China
Abstract
AbstractAdolescent idiopathic scoliosis (AIS) is a common spinal deformity in young women, but its pathogenesis remains unclear. The primary pathogenic factors contributing to its development include genetics, abnormal bone metabolism, and endocrine factors. Bone marrow stem cells (BMSCs) play a crucial role in the pathogenesis of AIS by regulating its occurrence and progression. Noncoding RNAs (ncRNAs) are also involved in the pathogenesis of AIS, and their role in regulating BMSCs in patients with AIS requires further evaluation. In this review, we discuss the relevant literature regarding the osteogenic, chondrogenic, and lipogenic differentiation of BMSCs. The corresponding mechanisms of ncRNA‐mediated BMSC regulation in patients with AIS, recent advancements in AIS and ncRNA research, and the importance of ncRNA translation profiling and multiomics are highlighted.
Subject
Cell Biology,Clinical Biochemistry,Physiology