Safranal induces DNA double-strand breakage and ER-stress-mediated cell death in hepatocellular carcinoma cells

Author:

Al-Hrout Ala’a,Chaiboonchoe AmphunORCID,Khraiwesh BaselORCID,Murali Chandraprabha,Baig Badriya,El-Awady Raafat,Tarazi Hamadeh,Alzahmi Amnah,Nelson David R.ORCID,Greish Yaser E.,Ramadan Wafaa,Salehi-Ashtiani KouroshORCID,Amin Amr

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference67 articles.

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2. Sherman, M. Hepatocellular carcinoma: Epidemiology, surveillance, and diagnosis. Seminars in Liver Disease 30, 3–16 (2010).

3. Nahon, P., Ganne-Carrié, N., Trinchet, J.-C. & Beaugrand, M. Hepatic iron overload and risk of hepatocellular carcinoma in cirrhosis. Gastroenterol. Clin. Biol. 34, 1–7 (2010).

4. Starley, B. Q., Calcagno, C. J. & Harrison, S. A. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 51, 1820–1832 (2010).

5. Kinghorn, A. D., Chin, Y.-W. & Swanson, S. M. Discovery of natural product anticancer agents from biodiverse organisms. Curr. Opin. Drug Discov. Devel. 12, 189–196 (2009).

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