Author:
Buczyńska Angelika,Sidorkiewicz Iwona,Kościuszko Maria,Adamska Agnieszka,Siewko Katarzyna,Dzięcioł Janusz,Szumowski Piotr,Myśliwiec Janusz,Szelachowska Małgorzata,Popławska-Kita Anna,Krętowski Adam
Abstract
AbstractAngioinvasion remains the important prognostic feature in papillary thyroid cancer (PTC) patients. Literature data indicates several markers that may be associated with oxidative stress and/or angioinvasion. Therefore, we assessed the utility of selected parameters in angioinvasion and metastasis screening in serum of PTC patients. Serum antioxidant capacity (TAC) and sirtuin 3 (SIRT3) levels were decreased (all p < 0.05) and both DNA/RNA oxidative stress damage products (DNA/RNA OSDP) and malondialdehyde (MDA) levels were increased in PTC patients with angioinvasion and metastasis (study group) when compared with PTC patients without these features (all p < 0.01). The highest screening utility in differentiation between angioinvasion and metastasis presence and absence in PTC patients was presented for DNA/RNA OSDP (AUC = 0.71), SIRT3 (AUC = 0.70), and TAC (AUC = 0.67) (all p < 0.05). Our study suggests that peripheral concentration of oxidative stress markers could be useful as angioinvasion and metastasis indicator in PTC patients.
Funder
internal financing of Medical University of Bialystok
Publisher
Springer Science and Business Media LLC
Cited by
6 articles.
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