Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

Abstract

Abstract Objective: To investigate the expression changes and mechanism of oxidative stress and IL-17 induced inflammatory factors in thyroid cancer with Hashimoto's thyroiditis. Method: 40 patients with thyroid cancer accompanied by Hashimoto's thyroiditis were selected as the PTC+HT group, 45 patients with simple thyroid cancer as the PTC group, 42 patients with simple Hashimoto's thyroiditis as the HT group, and 40 healthy individuals as the control group (NC). Evaluate the oxidative stress indicators NO, eNOS, superoxide dismutase (SOD), inflammatory indicators IL-17A, IL-1β and IL-6, thyroid hormones and their antibodies TPOAb and TGAb, as well as related biochemical indicators. Result: The inflammatory and oxidative stress indicators such as IL-17A were significantly increased in the PTC and HT groups compared to the control group, while the PTC+HT group further increased; There was a significant difference in thyroid hormone levels between the PTC+HT group and the HT group compared to the control group (P<0.05); TPOAb, TGAb and NO, eNOS, IL-17A, IL-1 β、IL-6 showed a significant positive correlation and a significant negative correlation with SOD (P<0.05); eNOS, SOD, and IL-17A are risk factors for these three different diseases. Conclusion: IL-17 and its induced inflammatory factors and oxidative stress are highly expressed in PTC+HT, and the synergistic effect between inflammation and oxidative stress leads to thyroid hormone levels and antibody abnormalities in PTC+HT patients. eNOS, SOD, and IL-17A can serve as effective indicators for predicting the occurrence and evaluating changes in PTC+HT disease, and also provide a theoretical basis for future treatment of PTC+HT.