Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1-Reference-Cited by-同舟云学术

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Published:2018-08-14 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Asai Yukako,Pan Bifeng^ORCID,Nist-Lund Carl,Galvin Alice,Lukashkin Andrei N.^ORCID,Lukashkina Victoria A.,Chen Tianwen,Zhou Wu,Zhu Hong,Russell Ian J.,Holt Jeffrey R.,Géléoc Gwenaelle S. G.

Funder

U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders

U.S. Department of Health & Human Services | NIH | National Eye Institute

Medical Research Council

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-28958-x.pdf

Reference38 articles.

1. Hudspeth, A. J. & Corey, D. P. Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli. Proc Natl Acad Sci USA 74, 2407–2411 (1977).

2. Corey, D. P. & Hudspeth, A. J. Ionic basis of the receptor potential in a vertebrate hair cell. Nature 281, 675–677 (1979).

3. Beurg, M., Fettiplace, R., Nam, J. H. & Ricci, A. J. Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging. Nat Neurosci 12, 553–558, https://doi.org/10.1038/nn.2295 (2009).

4. Kurima, K. et al. Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. Nat Genet 30, 277–284, https://doi.org/10.1038/ng842 (2002).

5. Vreugde, S. et al. Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet 30, 257–258, https://doi.org/10.1038/ng848 (2002).

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